The group focuses on the morphological development of the human hippocampal formation and that of the temporal neocortex. In connection with it, we investigate the role of abnormal development of the archi- and neocortical areas of the temporal lobe in the development of hippocampal sclerosis related temporal lobe epilepsy (TLE). Special attention is given to the effect of complex childhood febrile seizure on the development of the temporal lobe structures and to the effect of non-steroid anti-inflammatory drugs on it and on the expression of proteins that play a role in intracellular signaling. In addition to the investigation of neurosurgically removed temporal lobe samples of TLE patients, we use animal and tissue culture models of febrile seizure.
The prevalence of epilepsy is 0.5-1% of the population. Two-thirds of the drug-resistant-epilepsies are temporal lobe epilepsies (TLE), which is the most frequent form of focal epilepsies. In about 60% of the TLE, sclerosis of the medial temporal lobe structures including sclerosis of the hippocampal formation are visible. More than 50% of the patients suffering from hippocampal sclerosis related epilepsy, complex childhood febrile seizure is an anamnestic data. However, the exact role of febrile seizure on the cellular development of the hippocampal formation and in the development of the hippocampal sclerosis related TLE are not fully understood.
Hungarian Brain Research Program