Research interest
The physiological stress response is essential for our daily survival and helps us to adapt to the ever changing environment. However, sustained uncontrollable stress can induce various dysfunctions and pathological alterations in our body. Our key interest is the structural plasticity of the brain in relation to stress.
We focus on stress-induced changes in neuronal plasticity affecting neuronal networks, adult neurogenesis as well as glial changes in the hippocampus and neocortex. We hypothesize that such stress-induced structural changes contribute to the pathophysiology of psychiatric disorders like depression or schizophrenia, but medications like antidepressant, antipsychotic treatment can also have influence.
We aim for translational research using multidisciplinary methods ranging from molecular biology to in vitro and in vivo imaging.
Clinical relevance
major depressive disorder, epilepsy, multiple sclerosis, Alzheimer's disease
Tools
BioRad PCR Konfokális mikroszkóp (Olympus FluoView 1000) MRI light microscopy
fluorescence microscopy
laser scanning microcopy
small animal MRI
Methods
Immunohistochemistry Magnetic Resonance Imaging (MRI) diffusion tensor imaging
functional magnetic resonance imaging
resting state functional connectivity
droplet PCR
clinical psychology tests
Representative publications
Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task
Nagy, S. A., Kürtös, Z., Németh, N., Perlaki, G., Csernela, E., Lakner, F. E., Dóczi, T., Czéh, B., & Simon, M.
Neurobiology of stress
()
DOI
Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats
Czéh, B., Vardya, I., Varga, Z., Febbraro, F., Csabai, D., Martis, L. S., Højgaard, K., Henningsen, K., Bouzinova, E. V., Miseta, A., Jensen, K., & Wiborg, O.
Frontiers in cellular neuroscience
()
DOI
Animal models of major depression and their clinical implications
Czéh, B., Fuchs, E., Wiborg, O., & Simon, M.
Progress in neuro-psychopharmacology & biological psychiatry
()
DOI
Chronic stress reduces the number of GABAergic interneurons in the adult rat hippocampus, dorsal-ventral and region-specific differences.
Czéh, B., Varga, Z. K., Henningsen, K., Kovács, G. L., Miseta, A., & Wiborg, O.
Hippocampus
()
DOI
Neuropathology of stress.
Lucassen P.J., Pruessner J., Sousa N., Almeida O.F., Van Dam A.M., Rajkowska G., Swaab D.F., Czeh B.
Acta Neuropathologica
(2014/127(1): 109-135.)
DOI |
PubMed |
Scopus
Funding
Hungarian Brain Research Program 3. Correlating circulating microRNA expression profiles with neuroimaging data in depressed patients. 2022-2025
Thematic Excellence Program 2021. Examining brain functions and brain diseases with a multidisciplinary approach. 2022-2025
Boldizsár Czéh (Dr)
E-mail: czeh.boldizsar@pte.hu
Centre for Neuroscience organises IV. PhD and TDK student conference
In memoriam - Prof. Dr. István Miklós Ábrahám