Stress can affect the cellular integrity and functioning of our brain. Traumatic or long-term stress can have deleterious effect on neuronal morphology and network functioning of limbic structures. The principal aim of our work is to understand the stress-induced cellular changes in the CNS. We use in vivo and post mortem quantitative neuroimaging techniques to investigate stress-induced changes in neuronal plasticity affecting neuronal networks, including adult neurogenesis and glial changes in the hippocampus and prefrontal cortex.
The stress-induced cellular changes are believed to contribute to the development of various stress-related psychiatric disorders like depressive disorders, PTSD, anxiety disorders or schizophrenia. We aim for translational research using multidisciplinary methods ranging from cell biology, animal models to clinical studies involving in vivo neuroimaging.
In vivo neuroimaging
Animal models of major depression and their clinical implications.
Czeh B., Fuchs E., Wiborg O., Simon M.
Progress in Neuro-Psychopharmacology and Biological Psychiatry (2016/64: 293-310.)
Antidepressants act directly on astrocytes: Evidences and functional consequences.
Czeh B., Di Benedetto B.
European Neuropsychopharmacology (2013/23(3): 171-185.)
Electron microscopic analysis of hippocampal axo-somatic synapses in a chronic stress model for depression.
Csabai D., Seress L., Varga Z., Abraham H., Miseta A., Wiborg O., Czeh B.
Hippocampus (2017/27(1): 17-27.)
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Neuropathology of stress.
Lucassen P.J., Pruessner J., Sousa N., Almeida O.F., Van Dam A.M., Rajkowska G., Swaab D.F., Czeh B.
Acta Neuropathologica (2014/127(1): 109-135.)
Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation.
Lucassen P.J., Oomen C.A., Naninck E.F.G., Fitzsimons C.P., van Dam A.M., Czeh B., Korosi A.
Cold Spring Harbor Perspectives in Biology (2015/7(9): a021303.)
National Brain Research Program (NAP-B and NAP-2), Lundbeck Foundation (Denmark), GINOP-2.3.3-15-2016-NKFIH-5997-1, GINOP-2.3.3-15-2016-6062-1, GINOP 2.3..3-15-2016-00012