Research groups
Molecular Neuroendocrinology Research Group
István Ábrahám (professor) E-mail: istvan.abraham@aok.pte.hu
Tel.: +36 (72) 536-000 (ext: 35095)
web: mn.aok.pte.hu
Research interest

Our research group investigates the effect of estrogen on neurons in the brain. Estrogen secreted from the ovary, as a classical feedback molecule, alters the function of several neuronal phenotypes. Although estrogen is primarily thought to alter the neuronal activity via modulating gene expression directly, it also exerts “non-classical” effects on neurons by altering signal transduction pathways. In our laboratory, we systematically characterize the mechanism and role of estrogen-induced “non-classical” effect on signalling molecules in neurons using immunohistochemistry, calcium imaging, single cell electrophysiology, single molecule detection and transgenic technology.

Clinical relevance

Alzheimer's disease, neurodegeneration, infertility

Tools
Total Internal Reflection Fluorescence Mikroszkóp (Olympus)
Methods
Egy-sejt elektrofiziológia
Élő sejten megvalósuló egyedi-molekula detekciós mikroszkópia
Konfokális lézer szkenning mikroszkópia
Transgenic technology
Representative publications
Dynamic changes in binding interaction networks of sex steroids establish their non-classical effects. Bálint M, Jeszenői N, Horváth I, Ábrahám IM, Hetényi Cs
Scientific Reports (NATURE PUBLISHING GROUP) (2017 Nov 1;7(1):14847)
DOI | PubMed
Non-classical effects of estradiol on cAMP responsive element binding protein phosphorylation in gonadotropin-releasing hormone neurons: mechanisms and role. Kwakowsky A, Cheong RY, Herbison AE, Abraham IM
Frontiers in Neuroendocrinology (2014 Jan;35(1):31-41.)
DOI | PubMed
The Role of cAMP Response Element Binding Protein in Estrogen Negative Feedback Control of Gonadotropin-Releasing Hormone Neurons. Kwakowsly A, Herbsion AE, Ábraham IM
Journal of Neuroscience (2012 Aug 15;32(33):11309-17.)
DOI | PubMed
Tracking of Single Receptor Molecule Mobility in Neuronal Membranes: A Quick Theoretical and Practical Guide Kwakowsky A, Potapov D, Abraham IM
Journal of Neuroendocrinology (2013 Nov;25(11):1231-7.)
DOI | PubMed
Treatment of beta amyloid 1-42 (Abeta1-42)-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo. Kwakowsky A, Potapov K, Kim S, Peppercorn K, Tate WP, Abraham IM
Scientific Reports (NATURE PUBLISHING GROUP) (2016 Feb 16;6:21101)
DOI | PubMed
Funding
Hungarian Brain Research Program (KTIA_NAP_13-2014-0001)
   
OTKA (112807)
   
EFOP-3.6.1.-16-2016-00004, Comprehensive Development for Implementing Smart Specialization Strategies at the University of Pécs,  

EFOP-3.6.2-16-2017-00008, The role of neuro-inflammation in neurodegeneration: from molecules to clinics     

GINOP-2.3.3-15-2016-00030, Nano-bio-imaging