The research group investigates the neuroimmune interactions in different acute and chronic inflammatory reactions, as well as in degenerative disorders.  The main areas of research are the next:

Investigation of the role of TRPA1 in neurodegenerative disease. Interactions between neurons and glial cells (astrocytes, microglia and oligodendrocytes) in mouse models of multiple sclerosis and Alzheimer’ disease. (PI: Dr. Kata Bölcskei)

Examination of the role of TRP channels in different skin conditions with special interest of allergic contact dermatitis and psoriasis using pharmacological and genetic tools. (PI: Dr. Ágnes Kemény)

The pharmacoinformatics research is focused on the development and applications of computer-aided tools of rational, target-based design. They are actively engaged in computational docking, molecular dynamics and other methods which can predict the atomic resolution structure and strength of target-ligand interactions.     (PI: Dr. Csaba Hetényi)

Investigating biological effects and functions of hydrogen sulfide, sodium polysulfide and dimethyl trisulfide with special emphasis on transient receptor potential ankyrin 1 (TRPA1) ion channel-mediated ones. (PI: Dr. Gabor Pozsgai)

Support of the research with the methods molecular genetics. Cloning of TRPV1, TRPA1 és SSTR1-5 receptors. Producing TRPV1, TRPA1 and SSTR1-5 receptor expressing cell lines. Execution of fluorescent and radioactive binding studies, producing conditional knock out animals. (PI: Dr. Zoltán Sándor)

AtheNA LUMINEX 100 (Luminex Corp.)
CyFlow Space flow citométer (Partec)
Fluoreszcens molekuláris tomográf
HPLC készülék
Luminex multiplex citokin-meghatározásra alkalmas készülék
Olympus BX-51 mikroszkóp DP-50 kamerával
Skyscan micro CT készülék
Szcintillációs Beta-számláló (Packard Tri-Carb 2800 TR)

(2016-2020): PEPSYS GINOP-2.3.2-15-2016-00050 – “Complexity of peptidergic signalization and its role in systemic diseases”

(2017-2020): EFOP-3.6.2 “Investigation of neuroinflammatory and neurodegenerative mechanisms from the molecule to bedsite”

(2015-2017): NKFIH-OTKA-NN-114458 “Investigation of TRP channel-mediated effects of hydrogen sulfide in animal models of acute and chronic arthritis”

(2017-2018) Richter Témapályázat RG-IPI-2016-TP10/042

“A TRPA1 receptor, mint potenciális gyógyszercélpont az Alzheimer-kór kezelésében”

(2017-2020) EFOP-3.6.2-16-2017-00006 LIVE LONGER „Modern orvostudományi diagnosztikus eljárások és terápiák fejlesztése transzlációs megközelítésben: a laboratóriumtól a betegágyig"

(2017-2020) STAY ALIVE GINOP-2.3.2-15-2016-00048 – “Excellence of R+D Strategic Centres: Improving the severity and lethality parameters of life-threatening diseases from a translational approach”

(2017-2020) NAP-2 “TRPA1 receptor as a potential drug target in neuroinflammation and neurodegenerative disorders”