Research groups
Molecular Neuroendocrinology Research Group
Research interest

Our research group investigates the effect of estrogen on neurons in the brain. Estrogen secreted from the ovary, as a classical feedback molecule, alters the function of several neuronal phenotypes. Although estrogen is primarily thought to alter the neuronal activity via modulating gene expression directly, it also exerts “non-classical” effects on neurons by altering signal transduction pathways. In our laboratory, we systematically characterize the mechanism and role of estrogen-induced “non-classical” effect on signalling molecules in neurons using immunohistochemistry, calcium imaging, single cell electrophysiology, single molecule detection and transgenic technology.

Clinical relevance

Alzheimer's disease, neurodegeneration, infertility

Total Internal Reflection Fluorescence Mikroszkóp (Olympus)
Egy-sejt elektrofiziológia
Élő sejten megvalósuló egyedi-molekula detekciós mikroszkópia
Konfokális lézer szkenning mikroszkópia
Transgenic technology
Representative publications
Dynamic changes in binding interaction networks of sex steroids establish their non-classical effects. Bálint M, Jeszenői N, Horváth I, Ábrahám IM, Hetényi Cs
Scientific Reports (NATURE PUBLISHING GROUP) (2017 Nov 1;7(1):14847)
DOI | PubMed
Non-classical effects of estradiol on cAMP responsive element binding protein phosphorylation in gonadotropin-releasing hormone neurons: mechanisms and role. Kwakowsky A, Cheong RY, Herbison AE, Abraham IM
Frontiers in Neuroendocrinology (2014 Jan;35(1):31-41.)
DOI | PubMed
The Role of cAMP Response Element Binding Protein in Estrogen Negative Feedback Control of Gonadotropin-Releasing Hormone Neurons. Kwakowsly A, Herbsion AE, Ábraham IM
Journal of Neuroscience (2012 Aug 15;32(33):11309-17.)
DOI | PubMed
Tracking of Single Receptor Molecule Mobility in Neuronal Membranes: A Quick Theoretical and Practical Guide Kwakowsky A, Potapov D, Abraham IM
Journal of Neuroendocrinology (2013 Nov;25(11):1231-7.)
DOI | PubMed
Treatment of beta amyloid 1-42 (Abeta1-42)-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo. Kwakowsky A, Potapov K, Kim S, Peppercorn K, Tate WP, Abraham IM
Scientific Reports (NATURE PUBLISHING GROUP) (2016 Feb 16;6:21101)
DOI | PubMed
The Role of Interleukin-10 in Mediating the Effect of Immune Challenge on Mouse Gonadotropin-Releasing Hormone Neurons In Vivo Barabás K, Barad Z, Dénes Á, Bhattarai JP, Han SK, Kiss E, Sármay G, Ábrahám IM
eNeuro (2018 Oct 15;5(5))
DOI | PubMed
Rapid non-classical effects of steroids on the membrane receptor dynamics and downstream signaling in neurons. Barabás K, Godó S, Lengyel F, Ernszt D, Pál J, Ábrahám IM
Hormones and Behavior (2018 May 19. pii: S0018-506X(18)30090-4.)
DOI | PubMed
Modulation of P2X7 purinergic receptor activity by extracellular Zn2+ in cultured mouse hippocampal astroglia. Kovács G, Környei Z, Tóth K, Baranyi M, Brunner J, Neubrandt M, Dénes Á, Sperlágh B.
Cell Calcium (2018 Jul 30;75:1-13.)
DOI | PubMed
Social Learning Requires Plasticity Enhanced by Fluoxetine Through Prefrontal Bdnf-TrkB Signaling to Limit Aggression Induced by Post-Weaning Social Isolation. Mikics E, Guirado R, Umemori J, Toth M, Biro L, Miskolczi C, Balazsfi D, Zelena D, Castren E, Haller J, Karpova NN
Neuropsychopharmacology (2018 Jan;43(2):235-245)
DOI | PubMed
Contribution of Vesicular Glutamate Transporters to Stress Response and Related Psychopathologies: Studies in VGluT3 Knockout Mice. Horvath HR, Fazekas CL, Balazsfi D, Jain SK, Haller J, Zelena D
Cell Mol Neurobiol . (2018 Jan;38(1):37-52.)
DOI | PubMed
Characterization of connexin36 gap junctions in the human outer retina. Kantor O., Benko Z., Enzsoly A., David C., Naumann A., Nitschke R., Szabo A., Palfi E., Orban J., Nyitrai M., Nemeth J., Szel A., Lukats A., Volgyi B.
Brain Structure and Function (206/221(6): 2963-2984.)
DOI | PubMed | Scopus
Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice Rijal S, Cho DH, Park SA, Jang SH, Ábrahám IM, Han SK
Int J Mol Sci . (2020 Aug 20;21(17):5991)
DOI | PubMed
Sex differences in rapid nonclassical action of 17β-oestradiol on intracellular signalling and oestrogen receptor α expression in basal forebrain cholinergic neurones in mouse. Kim S, Barad Z, Cheong RY, Ábrahám IM
J Neuroendocrinol. (2020 Jan;32(1):e12830)
DOI | PubMed
Estradiol-Induced Epigenetically Mediated Mechanisms and Regulation of Gene Expression Tamás Kovács , Edina Szabó-Meleg , István M Ábrahám
Int J Mol Sci. (2020 Apr 30;21(9):E3177)
DOI | PubMed
Effect of inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences Barabás K, Szabó-Meleg E, Ábrahám IM
Int J Mol Sci. (2020 Jan 14;21(2):529)
DOI | PubMed
Hungarian Brain Research Program (KTIA_NAP_13-2014-0001)
OTKA (112807)
EFOP-3.6.1.-16-2016-00004, Comprehensive Development for Implementing Smart Specialization Strategies at the University of Pécs,  

EFOP-3.6.2-16-2017-00008, The role of neuro-inflammation in neurodegeneration: from molecules to clinics     

GINOP-2.3.3-15-2016-00030, Nano-bio-imaging