In the past 15 years we have been studying the neurodegeneration of the retina in different experimental pathological conditions (diabetic retinopathy, retinal ischemia, excitotoxic retinal damage) in rats and mice. We have applied different neuroprotective treatments to decrease the damege and observe the cellular and molecular mechanisms underlying the tissue injury and retinoprotection. We have put particular emphasis  on PACAP-induced neuroprotection.

Recently we have also started to investigate the effect of PACAP KO on retinal aging in mice, as well as the normal aging process in rats and mice. Along with the aging process, we also started to explore the role of non-conventional signaling pathways in postnatal retina development. We are interested mostly in the microRNA-indiced changes of gene expression. We are developing tools to visualize miRNA expression together with cellular and synaptic markers of retinal neuron. 

We wish to provide preclinikal models for several retinal pathologies (e.g. diabetic retinopathy, glaucoma) and provide full description of cellular and molecular events in model animals. These studies may help to understand the biological backgroung, plan therapies and diagnostic tolls as well as to identify potential drug targets.

Elektronmikroszkópia
microarray
PCR
Rutin hisztológiai eljárások
Western blot

KTIA - NAP 1. és NAP2.

NKFIH 119289

EFOP-3.6.2-16-2017-00008