Research groups
Neurobiology of Stress Research Group
Boldizsár Czéh (Dr) E-mail:
Tel.: +36 (72) 536-000 (ext: 29301)
Research interest

The physiological stress response is essential for our daily survival and helps us to adapt to the ever changing environment. However, sustained uncontrollable stress can induce various dysfunctions and pathological alterations in our body. Our key interest is the structural plasticity of the brain in relation to stress.
We focus on stress-induced changes in neuronal plasticity affecting neuronal networks, adult neurogenesis as well as glial changes in the hippocampus and neocortex. We hypothesize that such stress-induced structural changes contribute to the pathophysiology of psychiatric disorders like depression or schizophrenia, but medications like antidepressant, antipsychotic treatment can also have influence. 
We aim for translational research using multidisciplinary methods ranging from molecular biology to in vitro and in vivo imaging.

Clinical relevance

major depressive disorder, epilepsy, multiple sclerosis, Alzheimer's disease

BioRad PCR
Konfokális mikroszkóp (Olympus FluoView 1000)
light microscopy
fluorescence microscopy
laser scanning microcopy
small animal MRI
Magnetic Resonance Imaging (MRI)
diffusion tensor imaging
functional magnetic resonance imaging
resting state functional connectivity
droplet PCR
clinical psychology tests
Representative publications
Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task Nagy, S. A., Kürtös, Z., Németh, N., Perlaki, G., Csernela, E., Lakner, F. E., Dóczi, T., Czéh, B., & Simon, M.
Neurobiology of stress ()
Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats Czéh, B., Vardya, I., Varga, Z., Febbraro, F., Csabai, D., Martis, L. S., Højgaard, K., Henningsen, K., Bouzinova, E. V., Miseta, A., Jensen, K., & Wiborg, O.
Frontiers in cellular neuroscience ()
Animal models of major depression and their clinical implications Czéh, B., Fuchs, E., Wiborg, O., & Simon, M.
Progress in neuro-psychopharmacology & biological psychiatry ()
Chronic stress reduces the number of GABAergic interneurons in the adult rat hippocampus, dorsal-ventral and region-specific differences. Czéh, B., Varga, Z. K., Henningsen, K., Kovács, G. L., Miseta, A., & Wiborg, O.
Hippocampus ()
Neuropathology of stress. Lucassen P.J., Pruessner J., Sousa N., Almeida O.F., Van Dam A.M., Rajkowska G., Swaab D.F., Czeh B.
Acta Neuropathologica (2014/127(1): 109-135.)
DOI | PubMed | Scopus

Hungarian Brain Research Program 3. Correlating circulating microRNA expression profiles with neuroimaging data in depressed patients.  2022-2025

Thematic Excellence Program 2021. Examining brain functions and brain diseases with a multidisciplinary approach. 2022-2025